Publicaciones últimos 5 años





1.- Morales, J.F., Alberca, L.N., Chuguransky, S., Di Ianni, M.E., Talevi, A. Ruiz, M.E. Molecular Topology and Other Promiscuity Determinants as Predictors of Therapeutic Class – A Theoretical Framework to Guide Drug Repositioning? (2018). Current Topics in Medicinal Chemistry, 18(13), pp. 1110-1122. DOI: 10.2174/1568026618666180801091642

2.- Palestro, P.H., Enrique, N., Goicoechea, S., Villalba, M.L., Sabatier, L.L., Martin, P., Milesi, V., Bruno Blanch, L.E., Gavernet, L. Searching for New Leads To Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents (2018). Journal of chemical information and modeling, 58(7), pp. 1331–1342. DOI: 10.1021/acs.jcim.7b00721.

3.- Bellera, C. L., Sbaraglini, M. L., Talevi, A. Modern Approaches for the Discovery of Anti-Infectious Drugs for the Treatment of Neglected Diseases (2018). Current Topics in Medicinal Chemistry , 18(5), pp. 369-381. DOI: 10.2174/1568026618666180509151146

4.- Alberca, L. N., Sbaraglini, M. L., Morales, J. F., Dietrich, R. C., Ruiz, D., Pino Martinez A., Miranda, C., Fraccaroli, L., Palestro, P., Alba Soto, C., Carrillo, C., Talevi, A. Cascade Ligand- and Structure-Based Virtual Screening to Identify New Trypanocidal Compounds Inhibiting Putrescine Uptake. (2018). Front. Cell. Infect. Microbiol.  DOI:10.3389/fcimb.2018.00173

5.- Sbaraglini, M.L., Bellera, C.L., Talevi, A. The Challenge of Finding New Therapies for Sleeping Sickness (2018) The Microbiology of Central Nervous System Infections, Chapter 14, pp. 279-303. DOI:10.1016/B978-0-12-813806-9.00014-7

6.- Scioli Montoto, S., Sbaraglini, M.L., Talevi, A., Couyoupetrou, M., Di Ianni, M., Pesce, G.O., Alvarez, V.A. Bruno-Blanch, L.E., Castro, G.R., Ruiz, M.E., Island, G.A. Carbamazepine-loaded solid lipid nanoparticles and nanostructured lipid carriers: physicochemical characterization and in vitro/in vivo evaluation (2018) Colloids and Surfaces B: Biointerfaces, In Press, DOI:10.1016/j.colsurfb.2018.03.052

7.- Dietrich, R.C., Alberca, L.N., Ruiz, M.D., Palestro, P.H., Carrillo, C., Talevi, A., Gavernet, L. Identification of cisapride as new inhibitor of putrescine uptake in Trypanosoma cruzi by combined ligand- and structure-based virtual screening (2018) European Journal of Medicinal Chemistry, 149, pp. 22-29.  DOI: 10.1016/j.ejmech.2018.02.006

8.- Bellera, C.L., Di Ianni, M.E., Talevi, A. The application of molecular topology for ulcerative colitis drug discovery (2018) Expert Opinion on Drug Discovery, 13 (1), pp. 89-101. DOI: 10.1080/17460441.2018.1396314


1.- Gantner, M.E., Peroni, R.N., Morales, J.F., Villalba, M.L., Ruiz, M.E., Talevi, A. Development and Validation of a Computational Model Ensemble for the Early Detection of BCRP/ABCG2 Substrates during the Drug Design Stage (2017) Journal of Chemical Information and Modeling, 57 (8), pp. 1868-1880. DOI: 10.1021/acs.jcim.7b00016

2.- Gantner, M.E., Alberca, L.N., Mercader, A.G., Bruno-Blanch, L.E., Talevi, A. Integrated application of enhanced replacement method and ensemble learning for the prediction of BCRP/ABCG2 substrates (2017) Current Bioinformatics, 12 (3), pp. 239-248. DOI: 10.2174/1574893611666151109193016

3.- Pastore, V., Wasowski, C., Martin, P., Enrique, A., Higgs, J., Bruno-Blanch, L.E., Milesi, V., Marder, M. N-propyl-2,2-diphenyl-2-hydroxyacetamide, a novel α-hydroxyamide with anticonvulsant, anxiolytic and antidepressant-like effects that inhibits voltage-gated sodium channels (2018) European Journal of Pharmacology, 819, pp. 270-280. DOI: 10.1016/j.ejphar.2017.11.048 

4.- Pisera-Fuster, A., Otero, S., Talevi, A., Bruno-Blanch, L., Bernabeu, R. Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol-induced seizures in zebrafish (2017) Synapse, 71 (4), art. no. e21961. DOI: 10.1002/syn.21961 

5.- Santana-Gómez, C.E., Orozco-Suárez, S.A., Talevi, A., Bruno-Blanch, L., Magdaleno-Madrigal, V.M., Fernández-Mas, R., Rocha, L. Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats(2017) NeuroToxicology, 59, pp. 110-120.  DOI: 10.1016/j.neuro.2017.01.009 

6.- Couyoupetrou, M., Gantner, M.E., Di Ianni, M.E., Palestro, P.H., Enrique, A.V., Gavernet, L., Ruiz, M.E., Pesce, G., Bruno-Blanch, L.E., Talevi, A. Computer-aided recognition of abc transporters substrates and its application to the development of new drugs for refractory epilepsy (2017) Mini-Reviews in Medicinal Chemistry, 17 (3), pp. 205-215. DOI: 10.2174/1389557516666161013103408 

7.- Enrique, A., Goicoechea, S., Castaño, R., Taborda, F., Rocha, L., Orozco, S., Girardi, E., Bruno Blanch, L.New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice (2017) Epilepsy Research, 129, pp. 8-16. DOI: 10.1016/j.eplepsyres.2016.10.012 

8.- Islan, G.A., Ruiz, M.E., Morales, J.F., Sbaraglini, M.L., Enrique, A.V., Burton, G., Talevi, A., Bruno-Blanch, L.E., Castro, G.R. Hybrid inhalable microparticles for dual controlled release of levofloxacin and DNase: Physicochemical characterization and in vivo targeted delivery to the lungs (2017) Journal of Materials Chemistry B, 5 (17), pp. 3132-3144.  DOI: 10.1039/c6tb03366k

9.- Sbaraglini, M.L., Talevi, A. Hybrid compounds as anti-infective agents (2017) Current Topics in Medicinal Chemistry, 17 (9), pp. 1080-1095. DOI: 10.2174/15680266166661609271609124

10.-  Talevi, A., Castro, G.R. Targeted therapies (2017) Mini-Reviews in Medicinal Chemistry, 17 (3), pp. 186-187.  DOI:


1.-  Talevi, A. Computational approaches for innovative antiepileptic drug discovery (2016) Expert Opinion on Drug Discovery, 11 (10), pp. 1001-1016. DOI: 10.1080/17460441.2016.1216965

2.-  Talevi, A. The importance of bioactivation in computer-guided drug repositioning. Why the parent drug is not always enough (2016) Current Topics in Medicinal Chemistry, 16 (19), pp. 2078-2087.

3.- Sbaraglini, M.L., Vanrell, M.C., Bellera, C.L., Benaim, G., Carrillo, C., Talevi, A., Romano, P.S. Neglected tropical protozoan diseases: Drug repositioning as a rational option (2016) Current Topics in Medicinal Chemistry, 16 (19), pp. 2201-2222.

4.-  Sbaraglini, M.L., Bellera, C.L., Fraccaroli, L., Larocca, L., Carrillo, C., Talevi, A., Alba Soto, C.D. Novel cruzipain inhibitors for the chemotherapy of chronic Chagas disease (2016) International Journal of Antimicrobial Agents, 48 (1), pp. 91-95. DOI: 10.1016/j.ijantimicag.2016.02.018

5.- Talevi, A. Tailored Multi-Target Agents. Applications and Design Considerations (2016) Current Pharmaceutical Design, 22 (21), pp. 3164-3170. DOI:

6.-  Alberca, L.N., Sbaraglini, M.L., Balcazar, D., Fraccaroli, L., Carrillo, C., Medeiros, A., Benitez, D., Comini, M., Talevi, A. Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning (2016) Journal of Computer-Aided Molecular Design, 30 (4), pp. 305-321. DOI: 10.1007/s10822-016-9903-6

7.-  Villalba, M.L., Enrique, A.V., Higgs, J., Castaño, R.A., Goicoechea, S., Taborda, F.D., Gavernet, L., Lick, I.D., Marder, M., Bruno Blanch, L.E. Novel sulfamides and sulfamates derived from amino esters: Synthetic studies and anticonvulsant activity (2016) European Journal of Pharmacology, 774, pp. 55-63. DOI: 10.1016/j.ejphar.2016.02.001

8.-  Villalba, M.L., Palestro, P., Ceruso, M., Gonzalez Funes, J.L., Talevi, A., Bruno Blanch, L., Supuran, C.T., Gavernet, L. Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action (2016) Bioorganic and Medicinal Chemistry, 24 (4), pp. 894-901. DOI: 10.1016/j.bmc.2016.01.012


1.-  Bellera, C.L., Di Ianni, M.E., Sbaraglini, M.L., Castro, E.A., Bruno-Blanch, L.E., Talevi, A. Knowledge-Based Drug Repurposing: A Rational Approach Towards the Identification of Novel Medical Applications of Known Drugs (2015) Frontiers in Computational Chemistry, 1, pp. 44-81. DOI: 10.1016/B978-1-60805-865-5.50002-2

2.-  Di Ianni, M.E., Del Valle, M.E., Enrique, A.V., Rosella, M.A., Bruno, F., Bruno-Blanch, L.E., Talevi, A. Computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside A (2015) Assay and Drug Development Technologies, 13 (6), pp. 313-318. DOI: 10.1089/adt.2015.29010.meddrrr

3.- Bellera, C.L., Balcazar, D.E., Vanrell, M.C., Casassa, A.F., Palestro, P.H., Gavernet, L., Labriola, C.A., Gálvez, J., Bruno-Blanch, L.E., Romano, P.S., Carrillo, C., Talevi, A. Computer-guided drug repurposing: Identification of trypanocidal activity of clofazimine, benidipine and saquinavir (2015) European Journal of Medicinal Chemistry, 93, pp. 338-348. DOI: 10.1016/j.ejmech.2015.01.065

4.-  Rocha, L., Santana-Gómez, C., Rosillo-de la Torre, A., Magdaleno-Madrigal, V., Alonso-Vanegas, M., Velasco, F., Bruno-Blanch, L. Epilepsy Therapeutics (2015) Brain Mapping: An Encyclopedic Reference, 3, pp. 887-894. DOI: 10.1016/B978-0-12-397025-1.00105-6

5.-  Di Ianni, M.E., Gantner, M.E., Ruiz, M.E., Castro, E.A., Bruno-Blanch, L.E., Talevi, A. Systematic comparison of the performance of different 2D and 3D ligand-based virtual screening methodologies to discover anticonvulsant drugs (2015). Combinatorial Chemistry and High Throughput Screening, 18 (4), pp. 387-398.

6.-  Di Ianni, M.E., Enrique, A.V., Del Valle, M.E., Aldana, B., Rosella, M.A., Rocha, L., Castro, E.A., Bruno-Blanch, L.E., Talevi, A. Is there a relationship between sweet taste and seizures? Anticonvulsant and proconvulsant effects of non-nutritive sweeteners (2015) Combinatorial Chemistry and High Throughput Screening, 18 (4), pp. 335-345.

7.- Talevi, A. Multi-target pharmacology: Possibilities and limitations of the “skeleton key approach” from a medicinal chemist perspective (2015) Frontiers in Pharmacology, 6 (SEP), art. no. 205, . DOI: 10.3389/fphar.2015.00205

8.- Bellera, C.L., Sbaraglini, M.L., Balcazar, D.E., Fraccaroli, L., Cristina Vanrell, M., Florencia Casassa, A., Labriola, C.A., Romano, P.S., Carrillo, C., Talevi, A. High-throughput drug repositioning for the discovery of new treatments for chagas disease (2015) Mini-Reviews in Medicinal Chemistry, 15 (3), pp. 182-193.


1.- Bellera, C.L., Balcazar, D.E., Alberca, L., Labriola, C.A., Talevi, A., Carrillo, C. Identification of levothyroxine antichagasic activity through computer-aided drug repurposing (2014) The Scientific World Journal, 2014, art. no. 279618,

2.-  Talevi, A., Gantner, M.E., Ruiz, M.E. Applications of nanosystems to anticancer drug therapy (Part I. nanogels, nanospheres, nanocapsules) (2014) Recent Patents on Anti-Cancer Drug Discovery, 9 (1), pp. 83-98

3.-  Ruiz, M.E., Gantner, M.E., Talevi, A. Applications of nanosystems to anticancer drug therapy (Part II. dendrimers, micelles, lipid-based nanosystems) (2014) Recent Patents on Anti-Cancer Drug Discovery, 9 (1), pp. 99-128.

4.- Bellera, C.L., Balcazar, D.E., Alberca, L., Labriola, C.A., Talevi, A., Carrillo, C. Application of computer-aided drug repurposing in the search of new cruzipain inhibitors: Discovery of amiodarone and bromocriptine inhibitory effects (2013) Journal of Chemical Information and Modeling, 53 (9), pp. 2402-2408.DOI: 10.1021/ci400284v

5.- Palestro, P.H., Gavernet, L., Estiu, G.L., Bruno Blanch, L.E. Docking applied to the prediction of the affinity of compounds to p-glycoprotein (2014) BioMed Research International, 2014, art. no. 358425, DOI: 10.1155/2014/358425

6.- Pastore, V., Wasowski, C., Higgs, J., Mangialavori, I.C., Bruno-Blanch, L.E., Marder, M. A synthetic bioisoster of trimethadione and phenytoin elicits anticonvulsant effect, protects the brain oxidative damage produced by seizures and exerts antidepressant action in mice (2014) European Neuropsychopharmacology, 24 (8), pp. 1405-1414. DOI: 10.1016/j.euroneuro.2014.04.005