![\"\"](\"http:\/\/lideb.biol.unlp.edu.ar\/wp-content\/uploads\/2017\/03\/contract-1-300x300.png\")
<\/h1>\n\u00a0<\/h2>\n\u00a0<\/h2>\n\u00a0<\/h2>\n2024<\/strong><\/span><\/h2>\n
\nBarrionuevo EM, Peralta E, Manzur De Nardi A, et al. In Silico Screening Identification of Fatty Acids and Fatty Acid Derivatives with Antiseizure Activity: In Vitro and In Vivo Validation<\/strong>.\u00a0Pharmaceutics<\/i>. 2024;16(8):996. Published 2024 Jul 27. https:\/\/doi.org\/10.3390\/pharmaceutics16080996<\/a><\/p>\nTalevi A, Bellera C. An update on the novel methods for the discovery of antiseizure and antiepileptogenic medications: where are we in 2024?<\/strong>.\u00a0Expert Opin Drug Discov<\/i>. 2024;19(8):975-990. https:\/\/doi.org\/10.1080\/17460441.2024.2373165<\/a><\/p>\nMorales JF, Ruiz ME, Stratford RE and Talevi A. Application of machine learning to predict unbound drug bioavailability in the brain<\/strong>. Front. Drug Discov 2024;<\/em> 4:1360732. https:\/\/doi.org\/10.3389\/fddsv.2024.1360732<\/a><\/p>\nTalevi A and Bellera CL (2024) Clustering of small molecules: new perspectives and their impact on natural product lead discovery.<\/strong>\u00a0Front. Nat. Produc.2024;<\/em>\u00a03:1367537. https:\/\/doi.org\/10.3389\/fntpr.2024.1367537<\/a><\/p>\nTalevi A. Computer-Aided Drug Discovery and Design: Recent Advances and Future Prospects<\/strong>.\u00a0Methods Mol Biol<\/i>. 2024;2714:1-20. doi:10.1007\/978-1-0716-3441-7_1<\/a><\/p>\n2023<\/strong><\/span><\/h2>\n
\nCorvi MM, Rossi F, Ganuza A, Alonso AM, Alberca LN, Dietrich RC, Gavernet L, Talevi A. Triclabendazole and clofazimine reduce replication and spermine uptake in vitro in Toxoplasma gondii<\/strong>. Parasitology Research 123(1):69 (2023). http:\/\/dx.doi.org\/10.1007\/s00436-023-08062-4<\/a><\/p>\nRivero Berti, I, Gantner, ME, Rodriguez, S, Islan, GA, F\u00e1varo, WJ, Talevi, A, Castro, GR, Dur\u00e1n, N. Potential biocide roles of violacein<\/strong>. Frontiers in Nanotechnology 5: 1186386 (2023). https:\/\/doi.org\/10.3389\/fnano.2023.1186386<\/a><\/p>\nMori Cort\u00e9s, N, Scioli Montoto, S, Ruiz, ME, Califano, A, Zaritzky, N, Lorenzo, G. Rheological properties and microstructure of thermodynamically stable microemulsions as factors influencing the release rate of liposoluble vitamins<\/strong>. Food Hydrocolloids 141: 108699 (2023). http:\/\/dx.doi.org\/10.1016\/j.foodhyd.2023.108699<\/a><\/p>\nBoztepe, T, Scioli Montoto, S, Gambaro, R, Ruiz, ME, Cabrera, S, Aleman, J, Islan, G, Castro, GR, Le\u00f3n, I. Design, synthesis, characterization and evaluation of the antitumoral activity of the anti-HT-29 colorectal cell line activity of novel 8-oxyquinolinate-platinum(II)-loaded nanostructured lipid carriers targeted with riboflavin.<\/strong> Pharmaceutics 15: 1021 (2023). https:\/\/doi.org\/10.3390\/pharmaceutics15031021<\/a><\/p>\nErdozain S, Barrionuevo E, Ripoll L, Mier P, Andrade-Navarro MA. Protein repeats evolve and emerge in giant viruses<\/strong>. J Struct Biol 215:107962 (2023). https:\/\/doi.org\/10.1016\/j.jsb.2023.107962<\/a><\/p>\nLlanos, M. A., Enrique, N., Esteban-L\u00f3pez, V., Scioli-Montoto, S., S\u00e1nchez-Benito, D., Ruiz, M. E., Milesi, V., L\u00f3pez, D. E., Talevi, A., Mart\u00edn, P., & Gavernet, L. (2023). A Combined Ligand- and Structure-Based Virtual Screening To Identify Novel NaV1.2 Blockers: In Vitro Patch Clamp Validation and In Vivo Anticonvulsant Activity<\/strong>. Journal of chemical information and modeling, 10.1021\/acs.jcim.3c00645. Advance online publication. https:\/\/doi.org\/10.1021\/acs.jcim.3c00645<\/a><\/p>\nMuraca, G., Ruiz, M. E., Gambaro, R. C., Scioli-Montoto, S., Sbaraglini, M. L., Padula, G., Cisneros, J. S., Chain, C. Y., \u00c1lvarez, V. A., Huck-Iriart, C., Castro, G. R., Pi\u00f1ero, M. B., Marchetto, M. I., Alba Soto, C., Islan, G. A., & Talevi, A. (2023). Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies<\/strong>. Beilstein journal of nanotechnology, 14, 804\u2013818. https:\/\/doi.org\/10.3762\/bjnano.14.66<\/a><\/p>\nRuatta, S. M., Prada Gori, D. N., Fl\u00f3 D\u00edaz, M., Lorenzelli, F., Perelmuter, K., Alberca, L. N., Bellera, C. L., Medeiros, A., L\u00f3pez, G. V., Ingold, M., Porcal, W., Dibello, E., Ihnatenko, I., Kunick, C., Incerti, M., Luzardo, M., Colobbio, M., Ramos, J. C., Manta, E., Minini, L., \u2026 Comini, M. A. (2023). Garbage in, garbage out: how reliable training data improved a virtual screening approach against SARS-CoV-2 MPro<\/strong>. Frontiers in pharmacology, 14, 1193282. https:\/\/doi.org\/10.3389\/fphar.2023.1193282<\/a><\/p>\nGarofalo, F. M., Sbaraglini, M. L., Barrionuevo, E. M., Peralta, E., Bonifazi, E. L., Talevi, A., & Gavernet, L. (2023). Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid<\/strong>. Future medicinal chemistry, 15(9), 735\u2013743. https:\/\/doi.org\/10.4155\/fmc-2022-0222<\/a><\/p>\nPrada Gori, D. N., Alberca, L. N., & Talevi, A. (2023). Making the most effective use of available computational methods for drug repositioning<\/strong>. Expert opinion on drug discovery, 18(5), 495\u2013503. https:\/\/doi.org\/10.1080\/17460441.2023.2198700<\/a><\/p>\nLlanos, M. A., Alberca, L. N., Ruiz, M. D., Sbaraglini, M. L., Miranda, C., Pino-Martinez, A., Fraccaroli, L., Carrillo, C., Alba Soto, C. D., Gavernet, L., & Talevi, A. (2023). A combined ligand and target-based virtual screening strategy to repurpose drugs as putrescine uptake inhibitors with trypanocidal activity<\/strong>. Journal of computer-aided molecular design, 37(2), 75\u201390. https:\/\/doi.org\/10.1007\/s10822-022-00491-0<\/a><\/p>\nPrada Gori D.N., Ruatta S., Fl\u00f3 M., Alberca L.N, Bellera C.L., Park S., Heo J., Lee H., Park K., Pritsch O., Shum D., Comini M., Talevi A. Drug Repurposing Screening Validated by Experimental Assays Identifies two Clinical DrugsTargeting SARS-CoV-2 Main Protease<\/strong> (2023). Frontiers in Drug Discovery<\/span>, 2, 1082065. https:\/\/doi.org\/10.3389\/fddsv.2022.1082065<\/a><\/span><\/p>\n2022<\/strong><\/span><\/h2>\n
\nPrada Gori D.N., Alberca L.N., Rodriguez S., Alice J.I., Llanos M., Bellera C.L., Talevi A. LIDeB Tools: A Latin American resource of freely available, open-source cheminformatics apps<\/strong> (2022). <\/span>Artificial Intelligence in the Life Sciences<\/a> 2, 10049. https:\/\/doi.org\/10.1016\/j.ailsci.2022.100049<\/a><\/span><\/p>\nPrada Gori D.N., Llanos M., Bellera C.L., Talevi A., Alberca L.N. iRaPCA and SOMoC: Development and Validation of Web Applications for New Approaches for the Clustering of Small Molecules<\/strong> (2022). Journal of Chemical Information and Modeling 62 (12), 2987-2998.\u00a0 10.1021\/acs.jcim.2c00265<\/a><\/p>\nLlanos M., Alberca L., Ruiz M.D., Sbaraglini M.L., Miranda C., Pino-Martinez A., Fraccaroli L., Carrillo C., Alba Soto C.D., Gavernet L., Talevi A. A Combined Ligand and Target-based Virtual Screening Strategy to Repurpose Drugs as Putrescine Uptake Inhibitors with Trypanocidal Activity<\/strong> (2022). Journal of Computer-Aided Molecular Design.\u00a0 https:\/\/doi.org\/10.1007\/s10822-022-00491-0<\/a><\/p>\nLlanos M., Ventura C., Mart\u00edn P., Enrique N., Felice J.I., Gavernet L., Milesi V. Novel Dimeric hHv1 Model and Structural Bioinformatic Analysis Reveal an ATP-Binding Site Resulting in a Channel Activating Effect<\/strong> (2022). Journal of Chemical Information and Modeling, 62, 13, pp. 3200\u20133212.\u00a0 https:\/\/doi.org\/10.1021\/acs.jcim.1c01396<\/a><\/p>\nLlanos M., Enrique N., Sbaraglini M.L., Garofalo F.M., Talevi A., Gavernet L., Mart\u00edn P. Structure-Based Virtual Screening Identifies Novobiocin, Montelukast, and Cinnarizine as TRPV1 Modulators with Anticonvulsant Activity In Vivo<\/strong> (2022). Journal of Chemical Information and Modeling, 62, 12, pp. 3008\u20133022.\u00a0 https:\/\/doi.org\/10.1021\/acs.jcim.2c00312<\/a><\/p>\nTalevi A., Morales J. F., Hather G., Podichetty J. T., Kim S., Bloomingdale P. C., Burton J., Brown J. D., Winterstein A. G., Schmidt S., White J. K. Machine Learning in Drug Discovery and Development Part 1: A Primer<\/strong> (2022) CPT: Pharmacometrics and Systems Pharmacology 9(3), 129-142.\u00a0 10.1002\/psp4.12491<\/p>\nTalevi A. Antiseizure Medication Discovery: Recent and Future Paradigm Shifts<\/strong> (2022) Epilepsia Open 7(S1), S133-S141. DOI: 10.1002\/epi4.12581<\/p>\nTalevi A. Potential Medicinal Effects and Applications of Stevia Constituents<\/strong> (2022) Phytochemistry Reviews 21(1), 161-178. DOI: 10.1007\/s11101-021-09753-5<\/a><\/p>\nGantner M.E., Llanos M.A., Garofalo F.M., Villalba M.L., Gavernet L. Computational and Synthetic Target-based Approaches to the Discovery of Novel Anticonvulsant Compounds<\/strong> (2021). Current Medicinal Chemistry, 28, 33, pp. 6866-6894. DOI: https:\/\/doi.org\/10.2174\/0929867328666210506161234<\/a><\/p>\nGantner M.E., Prada Gori D.N., Llanos M.A., Talevi A., Angeli A., Vullo D., Supuran C.T., Gavernet L. Identification of New Carbonic Anhydrase VII Inhibitors by Structure-Based Virtual Screening<\/strong> (2022) Journal of Chemical Information and Modeling, 62,19, pp. 4760-4770. DOI: https:\/\/doi.org\/10.1021\/acs.jcim.2c00910<\/a><\/p>\nScioli Montoto, S.; Sbaraglini, M.L.; Cisneros, S.; Chain, Y.; Ferretti, V.; Le\u00f3n, I.; Alvarez, V.; Castro, G.; Islan, G.; Talevi, A.; Ruiz, M.E. Novel Phenobarbital-loaded nanostructured lipid carriers for epilepsy treatment: from QbD to in vivo evaluation<\/strong> (2022). Front Chem 10:908386. DOI: https:\/\/doi.org\/10.3389\/fchem.2022.908386 <\/a><\/p>\nLlanos M., Alberca L., Vilchez Larrea S., Schoijet A., Alonso G., Bellera C., Gavernet L., Talevi A. Homology Modeling and Molecular Dynamics Simulations of Trypanosoma cruzi Phosphodiesterase b1<\/strong> (2021). Chemistry and Biodiversity, 19, 1, pp. n\/a-n\/a. DOI: https:\/\/doi.org\/10.1002\/cbdv.202100712<\/a><\/p>\nCeschan, N.E.; Scioli Montoto, S.; Sbaraglini, M.L.; Ruiz, M.E.; Smyth, H.D.; Bucal\u00e1, V.; Ram\u00edrez-Rigo, M.V. Nebulization of a polyelectrolyte-drug system for systemic hypertension treatment<\/strong> (2022) Eur J Pharm Sci 170: 106108. DOI: https:\/\/doi.org\/10.1016\/j.ejps.2021.106108<\/a><\/p>\nFallico M., Alberca L.N., Gori D.N.P., Gavernet L., Talevi A. Machine Learning Search of Novel Selective NaV1.2 and NaV1.6 Inhibitors as Potential Treatment Against Dravet Syndrome<\/strong> (2022). Ribeiro, P.R.d.A., Cota, V.R., Barone, D.A.C., de Oliveira, A.C.M. (eds) Computational Neuroscience. LAWCN 2021. Communications in Computer and Information Science, vol 1519. Springer, Cham. DOI: https:\/\/doi.org\/10.1007\/978-3-031-08443-0_7<\/a><\/p>\n\u00a0<\/h2>\n2021<\/strong><\/span><\/h2>\n
\nLlanos M., Gantner M., Rodriguez S., Alberca L., Bellera C.L., Talevi A., Gavernet L.\u00a0Strengths and Weaknesses of Docking Simulations in the SARS-CoV-2 Era: the Main Protease (Mpro) Case Study <\/span><\/strong>(2021). Journal of Chemical Information and Modelling, 61,8, pp. 3758-3770.<\/span> DOI: https:\/\/doi.org\/10.1021\/acs.jcim.1c00404<\/a><\/p>\nAlice J. I., Bellera C. L., Ben\u00edtez D., Comini M. A., Duchowicz P. R., & Talevi A. (2021). Ensemble learning application to discover new trypanothione synthetase inhibitors.<\/strong> Molecular diversity<\/i>, 25<\/i>(3), 1361\u20131373.<\/span> https:\/\/doi.org\/10.1007\/s11030-021-10265-9<\/a><\/p>\nEnrique A. V., Di Ianni M. E., Goicoechea S., Lazarowski A., Valle-Dorado M. G., Costa J., Rocha L., Girardi E., & Talevi A. (2021). New anticonvulsant candidates prevent P-glycoprotein (P-gp) overexpression in a pharmacoresistant seizure model in mice.<\/strong> Epilepsy & behavior : E&B<\/i>, 121<\/i>(Pt B), 106451.<\/span> https:\/\/doi.org\/10.1016\/j.yebeh.2019.106451<\/a><\/p>\nS. Scioli Montoto, G. Muraca, M. Di Ianni, M. Couyoupetrou, G. Pesce, G.A. Islan, C.Y. Chain, M.E. Vela, M.E. Ruiz, A. Talevi, G.R. Castro. (2021). Preparation, physicochemical and biopharmaceutical characterization of oxcarbazepine-loaded nanostructured lipid carriers as potential antiepileptic devices,<\/strong> Journal of Drug Delivery Science and Technology, 63,102470.<\/span> https:\/\/doi.org\/10.1016\/j.jddst.2021.102470<\/a><\/span><\/p>\nTalevi, A. Potential medicinal effects and applications of stevia constituents.<\/strong> Phytochem Rev<\/i><\/span>. https:\/\/doi.org\/10.1007\/s11101-021-09753-5<\/a><\/p>\nTalevi, A., Duran, N., & Castro, G. R. (2021). Editorial: Lipid Nanoparticles as a Novel Strategy to Deliver Bioactive Molecules.<\/strong> <\/span>Frontiers in ch<\/span>emistry<\/i>, 9<\/i>, 655480. https:\/\/doi.org\/10.3389\/fchem.2021.655480<\/a><\/p>\nBellera, C., Llanos M., Gantner M., Rodriguez S., Gavernet L., Comini M., Talevi A. Can drug repurposing strategies be the solution to the COVID-19 crisis?<\/strong> (2<\/span>021). Expert Opinion on Drug Discovery,\u00a0 pp. 605-612. DOI: https:\/\/doi.org\/10.1080\/17460441.2021.1863943<\/a><\/p>\n2020<\/strong><\/span><\/h2>\n
\nScioli Montoto, S., Muraca G., Ruiz, M.E. Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects<\/strong> (2020<\/span>). Frontiers in Molecular Biosciences, 7, pp. 1-24. DOI:
\u00a0<\/h2>\n2024<\/strong><\/span><\/h2>\n
\nBarrionuevo EM, Peralta E, Manzur De Nardi A, et al. In Silico Screening Identification of Fatty Acids and Fatty Acid Derivatives with Antiseizure Activity: In Vitro and In Vivo Validation<\/strong>.\u00a0Pharmaceutics<\/i>. 2024;16(8):996. Published 2024 Jul 27. https:\/\/doi.org\/10.3390\/pharmaceutics16080996<\/a><\/p>\nTalevi A, Bellera C. An update on the novel methods for the discovery of antiseizure and antiepileptogenic medications: where are we in 2024?<\/strong>.\u00a0Expert Opin Drug Discov<\/i>. 2024;19(8):975-990. https:\/\/doi.org\/10.1080\/17460441.2024.2373165<\/a><\/p>\nMorales JF, Ruiz ME, Stratford RE and Talevi A. Application of machine learning to predict unbound drug bioavailability in the brain<\/strong>. Front. Drug Discov 2024;<\/em> 4:1360732. https:\/\/doi.org\/10.3389\/fddsv.2024.1360732<\/a><\/p>\nTalevi A and Bellera CL (2024) Clustering of small molecules: new perspectives and their impact on natural product lead discovery.<\/strong>\u00a0Front. Nat. Produc.2024;<\/em>\u00a03:1367537. https:\/\/doi.org\/10.3389\/fntpr.2024.1367537<\/a><\/p>\nTalevi A. Computer-Aided Drug Discovery and Design: Recent Advances and Future Prospects<\/strong>.\u00a0Methods Mol Biol<\/i>. 2024;2714:1-20. doi:10.1007\/978-1-0716-3441-7_1<\/a><\/p>\n2023<\/strong><\/span><\/h2>\n
\nCorvi MM, Rossi F, Ganuza A, Alonso AM, Alberca LN, Dietrich RC, Gavernet L, Talevi A. Triclabendazole and clofazimine reduce replication and spermine uptake in vitro in Toxoplasma gondii<\/strong>. Parasitology Research 123(1):69 (2023). http:\/\/dx.doi.org\/10.1007\/s00436-023-08062-4<\/a><\/p>\nRivero Berti, I, Gantner, ME, Rodriguez, S, Islan, GA, F\u00e1varo, WJ, Talevi, A, Castro, GR, Dur\u00e1n, N. Potential biocide roles of violacein<\/strong>. Frontiers in Nanotechnology 5: 1186386 (2023). https:\/\/doi.org\/10.3389\/fnano.2023.1186386<\/a><\/p>\nMori Cort\u00e9s, N, Scioli Montoto, S, Ruiz, ME, Califano, A, Zaritzky, N, Lorenzo, G. Rheological properties and microstructure of thermodynamically stable microemulsions as factors influencing the release rate of liposoluble vitamins<\/strong>. Food Hydrocolloids 141: 108699 (2023). http:\/\/dx.doi.org\/10.1016\/j.foodhyd.2023.108699<\/a><\/p>\nBoztepe, T, Scioli Montoto, S, Gambaro, R, Ruiz, ME, Cabrera, S, Aleman, J, Islan, G, Castro, GR, Le\u00f3n, I. Design, synthesis, characterization and evaluation of the antitumoral activity of the anti-HT-29 colorectal cell line activity of novel 8-oxyquinolinate-platinum(II)-loaded nanostructured lipid carriers targeted with riboflavin.<\/strong> Pharmaceutics 15: 1021 (2023). https:\/\/doi.org\/10.3390\/pharmaceutics15031021<\/a><\/p>\nErdozain S, Barrionuevo E, Ripoll L, Mier P, Andrade-Navarro MA. Protein repeats evolve and emerge in giant viruses<\/strong>. J Struct Biol 215:107962 (2023). https:\/\/doi.org\/10.1016\/j.jsb.2023.107962<\/a><\/p>\nLlanos, M. A., Enrique, N., Esteban-L\u00f3pez, V., Scioli-Montoto, S., S\u00e1nchez-Benito, D., Ruiz, M. E., Milesi, V., L\u00f3pez, D. E., Talevi, A., Mart\u00edn, P., & Gavernet, L. (2023). A Combined Ligand- and Structure-Based Virtual Screening To Identify Novel NaV1.2 Blockers: In Vitro Patch Clamp Validation and In Vivo Anticonvulsant Activity<\/strong>. Journal of chemical information and modeling, 10.1021\/acs.jcim.3c00645. Advance online publication. https:\/\/doi.org\/10.1021\/acs.jcim.3c00645<\/a><\/p>\nMuraca, G., Ruiz, M. E., Gambaro, R. C., Scioli-Montoto, S., Sbaraglini, M. L., Padula, G., Cisneros, J. S., Chain, C. Y., \u00c1lvarez, V. A., Huck-Iriart, C., Castro, G. R., Pi\u00f1ero, M. B., Marchetto, M. I., Alba Soto, C., Islan, G. A., & Talevi, A. (2023). Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies<\/strong>. Beilstein journal of nanotechnology, 14, 804\u2013818. https:\/\/doi.org\/10.3762\/bjnano.14.66<\/a><\/p>\nRuatta, S. M., Prada Gori, D. N., Fl\u00f3 D\u00edaz, M., Lorenzelli, F., Perelmuter, K., Alberca, L. N., Bellera, C. L., Medeiros, A., L\u00f3pez, G. V., Ingold, M., Porcal, W., Dibello, E., Ihnatenko, I., Kunick, C., Incerti, M., Luzardo, M., Colobbio, M., Ramos, J. C., Manta, E., Minini, L., \u2026 Comini, M. A. (2023). Garbage in, garbage out: how reliable training data improved a virtual screening approach against SARS-CoV-2 MPro<\/strong>. Frontiers in pharmacology, 14, 1193282. https:\/\/doi.org\/10.3389\/fphar.2023.1193282<\/a><\/p>\nGarofalo, F. M., Sbaraglini, M. L., Barrionuevo, E. M., Peralta, E., Bonifazi, E. L., Talevi, A., & Gavernet, L. (2023). Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid<\/strong>. Future medicinal chemistry, 15(9), 735\u2013743. https:\/\/doi.org\/10.4155\/fmc-2022-0222<\/a><\/p>\nPrada Gori, D. N., Alberca, L. N., & Talevi, A. (2023). Making the most effective use of available computational methods for drug repositioning<\/strong>. Expert opinion on drug discovery, 18(5), 495\u2013503. https:\/\/doi.org\/10.1080\/17460441.2023.2198700<\/a><\/p>\nLlanos, M. A., Alberca, L. N., Ruiz, M. D., Sbaraglini, M. L., Miranda, C., Pino-Martinez, A., Fraccaroli, L., Carrillo, C., Alba Soto, C. D., Gavernet, L., & Talevi, A. (2023). A combined ligand and target-based virtual screening strategy to repurpose drugs as putrescine uptake inhibitors with trypanocidal activity<\/strong>. Journal of computer-aided molecular design, 37(2), 75\u201390. https:\/\/doi.org\/10.1007\/s10822-022-00491-0<\/a><\/p>\nPrada Gori D.N., Ruatta S., Fl\u00f3 M., Alberca L.N, Bellera C.L., Park S., Heo J., Lee H., Park K., Pritsch O., Shum D., Comini M., Talevi A. Drug Repurposing Screening Validated by Experimental Assays Identifies two Clinical DrugsTargeting SARS-CoV-2 Main Protease<\/strong> (2023). Frontiers in Drug Discovery<\/span>, 2, 1082065. https:\/\/doi.org\/10.3389\/fddsv.2022.1082065<\/a><\/span><\/p>\n2022<\/strong><\/span><\/h2>\n
\nPrada Gori D.N., Alberca L.N., Rodriguez S., Alice J.I., Llanos M., Bellera C.L., Talevi A. LIDeB Tools: A Latin American resource of freely available, open-source cheminformatics apps<\/strong> (2022). <\/span>Artificial Intelligence in the Life Sciences<\/a> 2, 10049. https:\/\/doi.org\/10.1016\/j.ailsci.2022.100049<\/a><\/span><\/p>\nPrada Gori D.N., Llanos M., Bellera C.L., Talevi A., Alberca L.N. iRaPCA and SOMoC: Development and Validation of Web Applications for New Approaches for the Clustering of Small Molecules<\/strong> (2022). Journal of Chemical Information and Modeling 62 (12), 2987-2998.\u00a0 10.1021\/acs.jcim.2c00265<\/a><\/p>\nLlanos M., Alberca L., Ruiz M.D., Sbaraglini M.L., Miranda C., Pino-Martinez A., Fraccaroli L., Carrillo C., Alba Soto C.D., Gavernet L., Talevi A. A Combined Ligand and Target-based Virtual Screening Strategy to Repurpose Drugs as Putrescine Uptake Inhibitors with Trypanocidal Activity<\/strong> (2022). Journal of Computer-Aided Molecular Design.\u00a0 https:\/\/doi.org\/10.1007\/s10822-022-00491-0<\/a><\/p>\nLlanos M., Ventura C., Mart\u00edn P., Enrique N., Felice J.I., Gavernet L., Milesi V. Novel Dimeric hHv1 Model and Structural Bioinformatic Analysis Reveal an ATP-Binding Site Resulting in a Channel Activating Effect<\/strong> (2022). Journal of Chemical Information and Modeling, 62, 13, pp. 3200\u20133212.\u00a0 https:\/\/doi.org\/10.1021\/acs.jcim.1c01396<\/a><\/p>\nLlanos M., Enrique N., Sbaraglini M.L., Garofalo F.M., Talevi A., Gavernet L., Mart\u00edn P. Structure-Based Virtual Screening Identifies Novobiocin, Montelukast, and Cinnarizine as TRPV1 Modulators with Anticonvulsant Activity In Vivo<\/strong> (2022). Journal of Chemical Information and Modeling, 62, 12, pp. 3008\u20133022.\u00a0 https:\/\/doi.org\/10.1021\/acs.jcim.2c00312<\/a><\/p>\nTalevi A., Morales J. F., Hather G., Podichetty J. T., Kim S., Bloomingdale P. C., Burton J., Brown J. D., Winterstein A. G., Schmidt S., White J. K. Machine Learning in Drug Discovery and Development Part 1: A Primer<\/strong> (2022) CPT: Pharmacometrics and Systems Pharmacology 9(3), 129-142.\u00a0 10.1002\/psp4.12491<\/p>\nTalevi A. Antiseizure Medication Discovery: Recent and Future Paradigm Shifts<\/strong> (2022) Epilepsia Open 7(S1), S133-S141. DOI: 10.1002\/epi4.12581<\/p>\nTalevi A. Potential Medicinal Effects and Applications of Stevia Constituents<\/strong> (2022) Phytochemistry Reviews 21(1), 161-178. DOI: 10.1007\/s11101-021-09753-5<\/a><\/p>\nGantner M.E., Llanos M.A., Garofalo F.M., Villalba M.L., Gavernet L. Computational and Synthetic Target-based Approaches to the Discovery of Novel Anticonvulsant Compounds<\/strong> (2021). Current Medicinal Chemistry, 28, 33, pp. 6866-6894. DOI: https:\/\/doi.org\/10.2174\/0929867328666210506161234<\/a><\/p>\nGantner M.E., Prada Gori D.N., Llanos M.A., Talevi A., Angeli A., Vullo D., Supuran C.T., Gavernet L. Identification of New Carbonic Anhydrase VII Inhibitors by Structure-Based Virtual Screening<\/strong> (2022) Journal of Chemical Information and Modeling, 62,19, pp. 4760-4770. DOI: https:\/\/doi.org\/10.1021\/acs.jcim.2c00910<\/a><\/p>\nScioli Montoto, S.; Sbaraglini, M.L.; Cisneros, S.; Chain, Y.; Ferretti, V.; Le\u00f3n, I.; Alvarez, V.; Castro, G.; Islan, G.; Talevi, A.; Ruiz, M.E. Novel Phenobarbital-loaded nanostructured lipid carriers for epilepsy treatment: from QbD to in vivo evaluation<\/strong> (2022). Front Chem 10:908386. DOI: https:\/\/doi.org\/10.3389\/fchem.2022.908386 <\/a><\/p>\nLlanos M., Alberca L., Vilchez Larrea S., Schoijet A., Alonso G., Bellera C., Gavernet L., Talevi A. Homology Modeling and Molecular Dynamics Simulations of Trypanosoma cruzi Phosphodiesterase b1<\/strong> (2021). Chemistry and Biodiversity, 19, 1, pp. n\/a-n\/a. DOI: https:\/\/doi.org\/10.1002\/cbdv.202100712<\/a><\/p>\nCeschan, N.E.; Scioli Montoto, S.; Sbaraglini, M.L.; Ruiz, M.E.; Smyth, H.D.; Bucal\u00e1, V.; Ram\u00edrez-Rigo, M.V. Nebulization of a polyelectrolyte-drug system for systemic hypertension treatment<\/strong> (2022) Eur J Pharm Sci 170: 106108. DOI: https:\/\/doi.org\/10.1016\/j.ejps.2021.106108<\/a><\/p>\nFallico M., Alberca L.N., Gori D.N.P., Gavernet L., Talevi A. Machine Learning Search of Novel Selective NaV1.2 and NaV1.6 Inhibitors as Potential Treatment Against Dravet Syndrome<\/strong> (2022). Ribeiro, P.R.d.A., Cota, V.R., Barone, D.A.C., de Oliveira, A.C.M. (eds) Computational Neuroscience. LAWCN 2021. Communications in Computer and Information Science, vol 1519. Springer, Cham. DOI: https:\/\/doi.org\/10.1007\/978-3-031-08443-0_7<\/a><\/p>\n\u00a0<\/h2>\n2021<\/strong><\/span><\/h2>\n
\nLlanos M., Gantner M., Rodriguez S., Alberca L., Bellera C.L., Talevi A., Gavernet L.\u00a0Strengths and Weaknesses of Docking Simulations in the SARS-CoV-2 Era: the Main Protease (Mpro) Case Study <\/span><\/strong>(2021). Journal of Chemical Information and Modelling, 61,8, pp. 3758-3770.<\/span> DOI: https:\/\/doi.org\/10.1021\/acs.jcim.1c00404<\/a><\/p>\nAlice J. I., Bellera C. L., Ben\u00edtez D., Comini M. A., Duchowicz P. R., & Talevi A. (2021). Ensemble learning application to discover new trypanothione synthetase inhibitors.<\/strong> Molecular diversity<\/i>, 25<\/i>(3), 1361\u20131373.<\/span> https:\/\/doi.org\/10.1007\/s11030-021-10265-9<\/a><\/p>\nEnrique A. V., Di Ianni M. E., Goicoechea S., Lazarowski A., Valle-Dorado M. G., Costa J., Rocha L., Girardi E., & Talevi A. (2021). New anticonvulsant candidates prevent P-glycoprotein (P-gp) overexpression in a pharmacoresistant seizure model in mice.<\/strong> Epilepsy & behavior : E&B<\/i>, 121<\/i>(Pt B), 106451.<\/span> https:\/\/doi.org\/10.1016\/j.yebeh.2019.106451<\/a><\/p>\nS. Scioli Montoto, G. Muraca, M. Di Ianni, M. Couyoupetrou, G. Pesce, G.A. Islan, C.Y. Chain, M.E. Vela, M.E. Ruiz, A. Talevi, G.R. Castro. (2021). Preparation, physicochemical and biopharmaceutical characterization of oxcarbazepine-loaded nanostructured lipid carriers as potential antiepileptic devices,<\/strong> Journal of Drug Delivery Science and Technology, 63,102470.<\/span> https:\/\/doi.org\/10.1016\/j.jddst.2021.102470<\/a><\/span><\/p>\nTalevi, A. Potential medicinal effects and applications of stevia constituents.<\/strong> Phytochem Rev<\/i><\/span>. https:\/\/doi.org\/10.1007\/s11101-021-09753-5<\/a><\/p>\nTalevi, A., Duran, N., & Castro, G. R. (2021). Editorial: Lipid Nanoparticles as a Novel Strategy to Deliver Bioactive Molecules.<\/strong> <\/span>Frontiers in ch<\/span>emistry<\/i>, 9<\/i>, 655480. https:\/\/doi.org\/10.3389\/fchem.2021.655480<\/a><\/p>\nBellera, C., Llanos M., Gantner M., Rodriguez S., Gavernet L., Comini M., Talevi A. Can drug repurposing strategies be the solution to the COVID-19 crisis?<\/strong> (2<\/span>021). Expert Opinion on Drug Discovery,\u00a0 pp. 605-612. DOI: https:\/\/doi.org\/10.1080\/17460441.2021.1863943<\/a><\/p>\n2020<\/strong><\/span><\/h2>\n
\nScioli Montoto, S., Muraca G., Ruiz, M.E. Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects<\/strong> (2020<\/span>). Frontiers in Molecular Biosciences, 7, pp. 1-24. DOI:
\n
Barrionuevo EM, Peralta E, Manzur De Nardi A, et al. In Silico Screening Identification of Fatty Acids and Fatty Acid Derivatives with Antiseizure Activity: In Vitro and In Vivo Validation<\/strong>.\u00a0Pharmaceutics<\/i>. 2024;16(8):996. Published 2024 Jul 27. https:\/\/doi.org\/10.3390\/pharmaceutics16080996<\/a><\/p>\n Talevi A, Bellera C. An update on the novel methods for the discovery of antiseizure and antiepileptogenic medications: where are we in 2024?<\/strong>.\u00a0Expert Opin Drug Discov<\/i>. 2024;19(8):975-990. https:\/\/doi.org\/10.1080\/17460441.2024.2373165<\/a><\/p>\n Morales JF, Ruiz ME, Stratford RE and Talevi A. Application of machine learning to predict unbound drug bioavailability in the brain<\/strong>. Front. Drug Discov 2024;<\/em> 4:1360732. https:\/\/doi.org\/10.3389\/fddsv.2024.1360732<\/a><\/p>\n Talevi A and Bellera CL (2024) Clustering of small molecules: new perspectives and their impact on natural product lead discovery.<\/strong>\u00a0Front. Nat. Produc.2024;<\/em>\u00a03:1367537. https:\/\/doi.org\/10.3389\/fntpr.2024.1367537<\/a><\/p>\n Talevi A. Computer-Aided Drug Discovery and Design: Recent Advances and Future Prospects<\/strong>.\u00a0Methods Mol Biol<\/i>. 2024;2714:1-20. doi:10.1007\/978-1-0716-3441-7_1<\/a><\/p>\n Corvi MM, Rossi F, Ganuza A, Alonso AM, Alberca LN, Dietrich RC, Gavernet L, Talevi A. Triclabendazole and clofazimine reduce replication and spermine uptake in vitro in Toxoplasma gondii<\/strong>. Parasitology Research 123(1):69 (2023). http:\/\/dx.doi.org\/10.1007\/s00436-023-08062-4<\/a><\/p>\n Rivero Berti, I, Gantner, ME, Rodriguez, S, Islan, GA, F\u00e1varo, WJ, Talevi, A, Castro, GR, Dur\u00e1n, N. Potential biocide roles of violacein<\/strong>. Frontiers in Nanotechnology 5: 1186386 (2023). https:\/\/doi.org\/10.3389\/fnano.2023.1186386<\/a><\/p>\n Mori Cort\u00e9s, N, Scioli Montoto, S, Ruiz, ME, Califano, A, Zaritzky, N, Lorenzo, G. Rheological properties and microstructure of thermodynamically stable microemulsions as factors influencing the release rate of liposoluble vitamins<\/strong>. Food Hydrocolloids 141: 108699 (2023). http:\/\/dx.doi.org\/10.1016\/j.foodhyd.2023.108699<\/a><\/p>\n Boztepe, T, Scioli Montoto, S, Gambaro, R, Ruiz, ME, Cabrera, S, Aleman, J, Islan, G, Castro, GR, Le\u00f3n, I. Design, synthesis, characterization and evaluation of the antitumoral activity of the anti-HT-29 colorectal cell line activity of novel 8-oxyquinolinate-platinum(II)-loaded nanostructured lipid carriers targeted with riboflavin.<\/strong> Pharmaceutics 15: 1021 (2023). https:\/\/doi.org\/10.3390\/pharmaceutics15031021<\/a><\/p>\n Erdozain S, Barrionuevo E, Ripoll L, Mier P, Andrade-Navarro MA. Protein repeats evolve and emerge in giant viruses<\/strong>. J Struct Biol 215:107962 (2023). https:\/\/doi.org\/10.1016\/j.jsb.2023.107962<\/a><\/p>\n Llanos, M. A., Enrique, N., Esteban-L\u00f3pez, V., Scioli-Montoto, S., S\u00e1nchez-Benito, D., Ruiz, M. E., Milesi, V., L\u00f3pez, D. E., Talevi, A., Mart\u00edn, P., & Gavernet, L. (2023). A Combined Ligand- and Structure-Based Virtual Screening To Identify Novel NaV1.2 Blockers: In Vitro Patch Clamp Validation and In Vivo Anticonvulsant Activity<\/strong>. Journal of chemical information and modeling, 10.1021\/acs.jcim.3c00645. Advance online publication. https:\/\/doi.org\/10.1021\/acs.jcim.3c00645<\/a><\/p>\n Muraca, G., Ruiz, M. E., Gambaro, R. C., Scioli-Montoto, S., Sbaraglini, M. L., Padula, G., Cisneros, J. S., Chain, C. Y., \u00c1lvarez, V. A., Huck-Iriart, C., Castro, G. R., Pi\u00f1ero, M. B., Marchetto, M. I., Alba Soto, C., Islan, G. A., & Talevi, A. (2023). Nanostructured lipid carriers containing benznidazole: physicochemical, biopharmaceutical and cellular in vitro studies<\/strong>. Beilstein journal of nanotechnology, 14, 804\u2013818. https:\/\/doi.org\/10.3762\/bjnano.14.66<\/a><\/p>\n Ruatta, S. M., Prada Gori, D. N., Fl\u00f3 D\u00edaz, M., Lorenzelli, F., Perelmuter, K., Alberca, L. N., Bellera, C. L., Medeiros, A., L\u00f3pez, G. V., Ingold, M., Porcal, W., Dibello, E., Ihnatenko, I., Kunick, C., Incerti, M., Luzardo, M., Colobbio, M., Ramos, J. C., Manta, E., Minini, L., \u2026 Comini, M. A. (2023). Garbage in, garbage out: how reliable training data improved a virtual screening approach against SARS-CoV-2 MPro<\/strong>. Frontiers in pharmacology, 14, 1193282. https:\/\/doi.org\/10.3389\/fphar.2023.1193282<\/a><\/p>\n Garofalo, F. M., Sbaraglini, M. L., Barrionuevo, E. M., Peralta, E., Bonifazi, E. L., Talevi, A., & Gavernet, L. (2023). Synthesis and biological evaluation of new antiseizure compounds derived from valproic acid<\/strong>. Future medicinal chemistry, 15(9), 735\u2013743. https:\/\/doi.org\/10.4155\/fmc-2022-0222<\/a><\/p>\n Prada Gori, D. N., Alberca, L. N., & Talevi, A. (2023). Making the most effective use of available computational methods for drug repositioning<\/strong>. Expert opinion on drug discovery, 18(5), 495\u2013503. https:\/\/doi.org\/10.1080\/17460441.2023.2198700<\/a><\/p>\n Llanos, M. A., Alberca, L. N., Ruiz, M. D., Sbaraglini, M. L., Miranda, C., Pino-Martinez, A., Fraccaroli, L., Carrillo, C., Alba Soto, C. D., Gavernet, L., & Talevi, A. (2023). A combined ligand and target-based virtual screening strategy to repurpose drugs as putrescine uptake inhibitors with trypanocidal activity<\/strong>. Journal of computer-aided molecular design, 37(2), 75\u201390. https:\/\/doi.org\/10.1007\/s10822-022-00491-0<\/a><\/p>\n Prada Gori D.N., Ruatta S., Fl\u00f3 M., Alberca L.N, Bellera C.L., Park S., Heo J., Lee H., Park K., Pritsch O., Shum D., Comini M., Talevi A. Drug Repurposing Screening Validated by Experimental Assays Identifies two Clinical DrugsTargeting SARS-CoV-2 Main Protease<\/strong> (2023). Frontiers in Drug Discovery<\/span>, 2, 1082065. https:\/\/doi.org\/10.3389\/fddsv.2022.1082065<\/a><\/span><\/p>\n Prada Gori D.N., Alberca L.N., Rodriguez S., Alice J.I., Llanos M., Bellera C.L., Talevi A. LIDeB Tools: A Latin American resource of freely available, open-source cheminformatics apps<\/strong> (2022). <\/span>Artificial Intelligence in the Life Sciences<\/a> 2, 10049. https:\/\/doi.org\/10.1016\/j.ailsci.2022.100049<\/a><\/span><\/p>\n Prada Gori D.N., Llanos M., Bellera C.L., Talevi A., Alberca L.N. iRaPCA and SOMoC: Development and Validation of Web Applications for New Approaches for the Clustering of Small Molecules<\/strong> (2022). Journal of Chemical Information and Modeling 62 (12), 2987-2998.\u00a0 10.1021\/acs.jcim.2c00265<\/a><\/p>\n Llanos M., Alberca L., Ruiz M.D., Sbaraglini M.L., Miranda C., Pino-Martinez A., Fraccaroli L., Carrillo C., Alba Soto C.D., Gavernet L., Talevi A. A Combined Ligand and Target-based Virtual Screening Strategy to Repurpose Drugs as Putrescine Uptake Inhibitors with Trypanocidal Activity<\/strong> (2022). Journal of Computer-Aided Molecular Design.\u00a0 https:\/\/doi.org\/10.1007\/s10822-022-00491-0<\/a><\/p>\n Llanos M., Ventura C., Mart\u00edn P., Enrique N., Felice J.I., Gavernet L., Milesi V. Novel Dimeric hHv1 Model and Structural Bioinformatic Analysis Reveal an ATP-Binding Site Resulting in a Channel Activating Effect<\/strong> (2022). Journal of Chemical Information and Modeling, 62, 13, pp. 3200\u20133212.\u00a0 https:\/\/doi.org\/10.1021\/acs.jcim.1c01396<\/a><\/p>\n Llanos M., Enrique N., Sbaraglini M.L., Garofalo F.M., Talevi A., Gavernet L., Mart\u00edn P. Structure-Based Virtual Screening Identifies Novobiocin, Montelukast, and Cinnarizine as TRPV1 Modulators with Anticonvulsant Activity In Vivo<\/strong> (2022). Journal of Chemical Information and Modeling, 62, 12, pp. 3008\u20133022.\u00a0 https:\/\/doi.org\/10.1021\/acs.jcim.2c00312<\/a><\/p>\n Talevi A., Morales J. F., Hather G., Podichetty J. T., Kim S., Bloomingdale P. C., Burton J., Brown J. D., Winterstein A. G., Schmidt S., White J. K. Machine Learning in Drug Discovery and Development Part 1: A Primer<\/strong> (2022) CPT: Pharmacometrics and Systems Pharmacology 9(3), 129-142.\u00a0 10.1002\/psp4.12491<\/p>\n Talevi A. Antiseizure Medication Discovery: Recent and Future Paradigm Shifts<\/strong> (2022) Epilepsia Open 7(S1), S133-S141. DOI: 10.1002\/epi4.12581<\/p>\n Talevi A. Potential Medicinal Effects and Applications of Stevia Constituents<\/strong> (2022) Phytochemistry Reviews 21(1), 161-178. DOI: 10.1007\/s11101-021-09753-5<\/a><\/p>\n Gantner M.E., Llanos M.A., Garofalo F.M., Villalba M.L., Gavernet L. Computational and Synthetic Target-based Approaches to the Discovery of Novel Anticonvulsant Compounds<\/strong> (2021). Current Medicinal Chemistry, 28, 33, pp. 6866-6894. DOI: https:\/\/doi.org\/10.2174\/0929867328666210506161234<\/a><\/p>\n Gantner M.E., Prada Gori D.N., Llanos M.A., Talevi A., Angeli A., Vullo D., Supuran C.T., Gavernet L. Identification of New Carbonic Anhydrase VII Inhibitors by Structure-Based Virtual Screening<\/strong> (2022) Journal of Chemical Information and Modeling, 62,19, pp. 4760-4770. DOI: https:\/\/doi.org\/10.1021\/acs.jcim.2c00910<\/a><\/p>\n Scioli Montoto, S.; Sbaraglini, M.L.; Cisneros, S.; Chain, Y.; Ferretti, V.; Le\u00f3n, I.; Alvarez, V.; Castro, G.; Islan, G.; Talevi, A.; Ruiz, M.E. Novel Phenobarbital-loaded nanostructured lipid carriers for epilepsy treatment: from QbD to in vivo evaluation<\/strong> (2022). Front Chem 10:908386. DOI: https:\/\/doi.org\/10.3389\/fchem.2022.908386 <\/a><\/p>\n Llanos M., Alberca L., Vilchez Larrea S., Schoijet A., Alonso G., Bellera C., Gavernet L., Talevi A. Homology Modeling and Molecular Dynamics Simulations of Trypanosoma cruzi Phosphodiesterase b1<\/strong> (2021). Chemistry and Biodiversity, 19, 1, pp. n\/a-n\/a. DOI: https:\/\/doi.org\/10.1002\/cbdv.202100712<\/a><\/p>\n Ceschan, N.E.; Scioli Montoto, S.; Sbaraglini, M.L.; Ruiz, M.E.; Smyth, H.D.; Bucal\u00e1, V.; Ram\u00edrez-Rigo, M.V. Nebulization of a polyelectrolyte-drug system for systemic hypertension treatment<\/strong> (2022) Eur J Pharm Sci 170: 106108. DOI: https:\/\/doi.org\/10.1016\/j.ejps.2021.106108<\/a><\/p>\n Fallico M., Alberca L.N., Gori D.N.P., Gavernet L., Talevi A. Machine Learning Search of Novel Selective NaV1.2 and NaV1.6 Inhibitors as Potential Treatment Against Dravet Syndrome<\/strong> (2022). Ribeiro, P.R.d.A., Cota, V.R., Barone, D.A.C., de Oliveira, A.C.M. (eds) Computational Neuroscience. LAWCN 2021. Communications in Computer and Information Science, vol 1519. Springer, Cham. DOI: https:\/\/doi.org\/10.1007\/978-3-031-08443-0_7<\/a><\/p>\n Llanos M., Gantner M., Rodriguez S., Alberca L., Bellera C.L., Talevi A., Gavernet L.\u00a0Strengths and Weaknesses of Docking Simulations in the SARS-CoV-2 Era: the Main Protease (Mpro) Case Study <\/span><\/strong>(2021). Journal of Chemical Information and Modelling, 61,8, pp. 3758-3770.<\/span> DOI: https:\/\/doi.org\/10.1021\/acs.jcim.1c00404<\/a><\/p>\n Alice J. I., Bellera C. L., Ben\u00edtez D., Comini M. A., Duchowicz P. R., & Talevi A. (2021). Ensemble learning application to discover new trypanothione synthetase inhibitors.<\/strong> Molecular diversity<\/i>, 25<\/i>(3), 1361\u20131373.<\/span> https:\/\/doi.org\/10.1007\/s11030-021-10265-9<\/a><\/p>\n Enrique A. V., Di Ianni M. E., Goicoechea S., Lazarowski A., Valle-Dorado M. G., Costa J., Rocha L., Girardi E., & Talevi A. (2021). New anticonvulsant candidates prevent P-glycoprotein (P-gp) overexpression in a pharmacoresistant seizure model in mice.<\/strong> Epilepsy & behavior : E&B<\/i>, 121<\/i>(Pt B), 106451.<\/span> https:\/\/doi.org\/10.1016\/j.yebeh.2019.106451<\/a><\/p>\n S. Scioli Montoto, G. Muraca, M. Di Ianni, M. Couyoupetrou, G. Pesce, G.A. Islan, C.Y. Chain, M.E. Vela, M.E. Ruiz, A. Talevi, G.R. Castro. (2021). Preparation, physicochemical and biopharmaceutical characterization of oxcarbazepine-loaded nanostructured lipid carriers as potential antiepileptic devices,<\/strong> Journal of Drug Delivery Science and Technology, 63,102470.<\/span> https:\/\/doi.org\/10.1016\/j.jddst.2021.102470<\/a><\/span><\/p>\n Talevi, A. Potential medicinal effects and applications of stevia constituents.<\/strong> Phytochem Rev<\/i><\/span>. https:\/\/doi.org\/10.1007\/s11101-021-09753-5<\/a><\/p>\n Talevi, A., Duran, N., & Castro, G. R. (2021). Editorial: Lipid Nanoparticles as a Novel Strategy to Deliver Bioactive Molecules.<\/strong> <\/span>Frontiers in ch<\/span>emistry<\/i>, 9<\/i>, 655480. https:\/\/doi.org\/10.3389\/fchem.2021.655480<\/a><\/p>\n Bellera, C., Llanos M., Gantner M., Rodriguez S., Gavernet L., Comini M., Talevi A. Can drug repurposing strategies be the solution to the COVID-19 crisis?<\/strong> (2<\/span>021). Expert Opinion on Drug Discovery,\u00a0 pp. 605-612. DOI: https:\/\/doi.org\/10.1080\/17460441.2021.1863943<\/a><\/p>\n Scioli Montoto, S., Muraca G., Ruiz, M.E. Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects<\/strong> (2020<\/span>). Frontiers in Molecular Biosciences, 7, pp. 1-24. DOI: 2023<\/strong><\/span><\/h2>\n
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